Orthobiologics
SELPHYL® PRP Injections in Oklahoma City
Platelet-rich plasma (PRP) is prepared from a patient's own blood. The blood is processed to concentrate plasma and platelets, which contain proteins involved in the body's response to tissue injury. Dr. Blythe uses the SELPHYL® system, which converts leukocyte-poor PRP into PRFM (platelet-rich fibrin matrix) — a gel-like form designed to improve delivery and retention at the treatment site. PRP/PRFM may be considered for selected joint and soft-tissue conditions after an orthopedic evaluation.
Why Dr. Blythe Uses SELPHYL
Dr. Joseph Blythe uses the SELPHYL® leukocyte-poor PRP system. This closed preparation system converts leukocyte-poor PRP into PRFM (platelet-rich fibrin matrix) — a gel-like form designed to minimize red and white blood-cell contamination, improve delivery, and provide a standardized preparation from a relatively small blood sample.
- Closed preparation system
- Leukocyte-poor PRP converted to PRFM (platelet-rich fibrin matrix)
- Reduced red-cell contamination
- Approximately six-minute centrifuge cycle
- Approximately 4 mL of PRFM from the single kit
- Approximately 8 mL of PRFM from the double kit
- Approximately 9 mL blood draw for the single kit
- Approximately 18 mL blood draw for the double kit
- Standardized preparation with less dependence on manual separation technique
Conditions Evaluated for Leukocyte-Poor PRP and PRFM Injection
SELPHYL® leukocyte-poor PRFM injection may be considered for selected patients with the following conditions. Evaluation includes a review of imaging, prior treatment history, and the specific anatomy involved.
- Knee osteoarthritis and knee joint conditions
Selected patients with mild-to-moderate knee osteoarthritis who have not responded to corticosteroid or hyaluronic acid injections may be evaluated. PRFM injection for knee osteoarthritis in Oklahoma City is one of the more evidence-supported applications of leukocyte-poor PRP.
- Shoulder and rotator cuff conditions
Rotator cuff tendinopathy, partial-thickness rotator cuff tears, and shoulder osteoarthritis may be evaluated. PRFM injection is not a substitute for surgical repair of full-thickness rotator cuff tears in appropriate candidates.
- Hip-region conditions
Early to moderate hip osteoarthritis, greater trochanteric pain syndrome, and labral irritation may be evaluated. Intra-articular hip injections may require fluoroscopic or ultrasound guidance depending on the anatomy.
- Tendons and tendon attachment sites
Chronic tendinopathy of the Achilles, patellar, or elbow tendons that has not responded to physical therapy and standard injection therapy may be considered for PRFM injection for tendon injuries in Oklahoma City.
- Sacroiliac joint and ligamentous conditions
Selected patients with sacroiliac joint degeneration or ligamentous laxity may be evaluated. SI joint injection with PRFM is considered on an individualized basis.
- Other musculoskeletal conditions
Other conditions may be considered when supported by the diagnosis, anatomy, and available clinical evidence. Dr. Blythe will advise whether PRFM injection is appropriate for your specific diagnosis at your evaluation.
Injection Guidance and Treatment Frequency
Many office-based injections are performed using the physical examination and established anatomic landmarks. When fluoroscopic guidance is clinically necessary, the procedure may be scheduled at a surgery center. Intra-articular hip procedures and other deep targets may require image guidance depending on the anatomy and treatment plan.
Many patients are treated with one PRP procedure. The recommended treatment volume and number of procedures depend on the diagnosis, treatment area, response, and clinical findings. Additional treatment is not automatically required.
Treatment Costs
Single Kit
$600
SELPHYL® PRFM treatment
- ~9 mL blood draw
- ~4 mL PRFM produced
- ~6-minute centrifuge cycle
Double Kit
$900
SELPHYL® PRFM treatment
- ~18 mL blood draw
- ~8 mL PRFM produced
- Double volume, single session
PRP is offered as a cash-pay service. The double-kit option delivers double the PRFM volume in the same single session — it is not a second appointment. Surgery-center, imaging, anesthesia, laboratory, or facility charges are separate when applicable.
Evidence and Limitations
Clinical evidence for PRP varies by diagnosis. Evidence is comparatively stronger for selected patients with mild-to-moderate knee osteoarthritis and certain tendon disorders, but study results and professional recommendations remain inconsistent. PRP/PRFM does not reliably regrow normal cartilage, reverse advanced arthritis, or eliminate the need for surgery.
PRP is prepared using FDA-cleared devices. Device clearance is not the same as FDA approval of PRP or PRFM injections for arthritis, tendon disorders, or other orthopedic conditions. Dr. Blythe will discuss the evidence and realistic expectations at your consultation.
Frequently Asked Questions
Selected references
- Kon E, et al. Platelet-rich plasma: intra-articular knee injections produced favorable results on degenerative cartilage lesions.
- Filardo G, et al. Platelet-rich plasma vs hyaluronic acid to treat knee degenerative pathology: study design and preliminary results of a randomized controlled trial.
- FDA: Platelet Rich Plasma (PRP) — Questions and Answers.
- Mishra A, Pavelko T. Treatment of chronic elbow tendinosis with buffered platelet-rich plasma. Am J Sports Med. 2006.
Schedule an Evaluation
An orthopedic evaluation is required before PRP is recommended. Call the office or submit a request online.